Early impaired axonal transport in a triple transgenic mouse model of Alzheimer’s disease
نویسندگان
چکیده
J. Kim, I-Y. Choi, M. L. Michaelis, and S-P. Lee Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, KS, United States, Department of Neurology, Molecular & Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, United States, Department of Pharmacology and Toxocology, University of Kansas, Lawrence, KS, United States, Department of Molecular & Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, United States
منابع مشابه
Quantitative in vivo measurement of early axonal transport deficits in a triple transgenic mouse model of Alzheimer's disease using manganese-enhanced MRI
Impaired axonal transport has been linked to the pathogenic processes of Alzheimer's disease (AD) in which axonal swelling and degeneration are prevalent. The development of non-invasive neuroimaging methods to quantitatively assess in vivo axonal transport deficits would be enormously valuable to visualize early, yet subtle, changes in the AD brain, to monitor the disease progression and to qu...
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